lunes, 20 de noviembre de 2017

The T cell in Sjogren’s syndrome: Force majeure, not spectateur

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Sjogren’s syndrome (SS) is marked by diffuse lymphocytic infiltration of exocrine glands and other tissues. Just how these ectopic lymphocytes cause disease has been an area of active investigation, particularly over the past two decades. Unlike most other diseases of lymphocytic infiltration, the salivary glands are accessible to biopsy, thus SS serves as a model for parallel autoimmune disorders of organ infiltration. The work of Professor Youinou and others has elegantly clarified the role of the B lymphocyte in the development of ectopic lymphoid tissue, and in the characteristic B-cell hyperactivity leading to autoantibodies, hypergammaglobulinemia, and sometimes lymphoma []. Yet glandular tissue in SS is – in most phases of the disease – overwhelmingly infiltrated by T lymphocytes. This article will emphasize recent advances in the understanding of these cells as agents of primary SS pathogenesis.

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