jueves, 22 de diciembre de 2016

Malnutrición: déficits nutricionales o carencias de nutrientes en etapa maternal o infancia, predisponen a diabetes tipo 2:

Imagen relacionada

Malnutrición: déficits nutricionales o carencias de nutrientes en etapa maternal o infancia, predisponen a diabetes tipo 2:

Conclusions


We propose a thrifty 'phenotype hypothesis' of the aetiology of Type 2 (non-insulin-dependent) diabetes. The essence of the hypothesis is that poor nutrition in foetal and early infant life are detrimental to the development and function of the Beta cells of the islets of Langerhans. Such defects of structure and function, which may include more complex features of islet anatomy such as the vasculature and innervation, predispose to the later development of Type 2 diabetes. 


Existing evidence points to a key role for
protein and amino acids in this process but other nutritional defects are not excluded. Indeed the complex interactions of the type and timing of nutritional defects in early life are suggested as underlying the pathogenesis of the variable abnormalities sometimes described as 'Syndrome X'. Whilst these early changes powerfully determine susceptibility, additional factors such as obesity, ageing, physical inactivity, and possibly other processes leading to insulin resistance must also play a role in deciding the time of onset and severity of Type 2 diabetes (Figure 1).

No hay comentarios:

Publicar un comentario